Molecular Genetic Applications to the Diagnosis of Non-Hodgkin’s Lymphoma

作者: Gregory J. Tsongalis , William N. Rezuke

DOI: 10.1007/978-1-59259-125-1_20

关键词:

摘要: The hematological malignancies can be broadly categorized into the malignant lymphomas. which include two major categories, non-Hodgkin’s lymphoma and Hodgkin’s disease; acute chronic lymphoid leukemias, may of B-cell or T-cell type; myelogenous leukemia (AML); myelodysplastic syndromes; myeloproliferative disorders. NHL accounts for 5% new cancer cases annually with 57,000 expected to diagnosed in 1999 (1). goal this chapter is focus on hematopathological approach diagnosis lymphomas molecular genetic methods, specifically Southern blotting polymerase chain reaction (PCR), are most commonly employed.

参考文章(88)
H Griesser, A Feller, K Lennert, M Minden, T W Mak, Rearrangement of the beta chain of the T cell antigen receptor and immunoglobulin genes in lymphoproliferative disorders. Journal of Clinical Investigation. ,vol. 78, pp. 1179- 1184 ,(1986) , 10.1172/JCI112700
Andreas Strasser, David L. Vaux, Suzanne Cory, Alan W. Harris, Jerry M. Adams, Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Research. ,vol. 59, ,(1999)
S. H. Landis, T. Murray, S. Bolden, P. A. Wingo, Cancer statistics, 1999. CA: A Cancer Journal for Clinicians. ,vol. 49, pp. 8- 31 ,(1999) , 10.3322/CANJCLIN.49.1.8
Jerry M Adams, Steven Gerondakis, Elizabeth Webb, Lynn M Corcoran, Suzanne Cory, None, Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 1982- 1986 ,(1983) , 10.1073/PNAS.80.7.1982
William N Rezuke, Evelyn C Abernathy, Gregory J Tsongalis, Molecular diagnosis of B- and T-cell lymphomas: fundamental principles and clinical applications Clinical Chemistry. ,vol. 43, pp. 1814- 1823 ,(1997) , 10.1093/CLINCHEM/43.10.1814
R. Taub, I. Kirsch, C. Morton, G. Lenoir, D. Swan, S. Tronick, S. Aaronson, P. Leder, Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 7837- 7841 ,(1982) , 10.1073/PNAS.79.24.7837
Louis P. Dehner, Ki-1 lymphoma. Pediatric pathology / affiliated with the International Paediatric Pathology Association. ,vol. 11, pp. 183- 190 ,(1991) , 10.3109/15513819109064756
&NA;, PCR-based alternative for diagnosis of immunoglobulin heavy chain gene rearrangement: principles, practice, and polemics. Diagnostic molecular pathology : the American journal of surgical pathology, part B. ,vol. 5, pp. 3- 9 ,(1996) , 10.1097/00019606-199603000-00002
Harold R. Schumacher, Dan Pankowsky, Karla M. Sendelbach, Gene rearrangements in the diagnosis of lymphoma/leukemia. American Journal of Clinical Pathology. ,vol. 96, pp. 436- 436 ,(1991) , 10.1093/AJCP/96.3.436