N6-(δ2-Isopentenyl)adenosine: Chemical Reactions, Biosynthesis, Metabolism, and Significance to the Structure and Function of †RNA

摘要: Publisher Summary This chapter reviews that modified nucleosides occur in DNA, rRNA, and tRNA. To assess their biological significance, most progress has been made with studies on arises mainly from the facts primary sequences of several tRNA molecules are now known three biochemical functions may be tested. The presumably placed specific locations for definite reasons, but nothing is yet about functions. Because structural variety, it impossible to treat as a single class nucleic acid components. Therefore, attempting significance function molecules, one must consider each type separately. majority constitute relatively simple modifications basic nucleoside structure. recognizes existence hypermodified result more complex alteration. discusses by distinct characteristics: (1) A large side chain; (2) functional group such hydroxyl, carboxyl, allylic double bond (3) location adjacent 3' end anticodon, considerable potential bearing reactivity molecule. It explores N 6 -(Δ 2 -lsopentenyl) adenoshe function, its mode biosynthesis, chemical properties relation occurrence.