The Use of Two Immunosuppressive Drugs, Cyclosporin A and Tacrolimus, to Inhibit Virus Replication and Apoptosis in Cells Infected with Feline Immunodeficiency Virus
作者： E. Mortola , Y. Endo , K. Ohno , T. Watari , H. Tsujimoto
关键词:
摘要: An in vitro model of acute and chronic infections with feline immunodeficiency virus (FIV) was used to examine the effect two immunosuppressive agents, cyclosporin A (CsA) tacrolimus (also known as FK506), on inhibition replication apoptosis. Both drugs significantly suppressed production a dose-dependent manner acutely chronically infected cells. The ability FK506 inhibit much lower than that CsA, accompanied by marked antiproliferative activity. Treatment cells either CsA or did not affect rise free intracellular Ca2+ but protect against Thus, antiviral activity makes these compounds promising candidates for development suitable treatment AIDS.
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D. J. McConkey, S. Orrenius, Calcium and Cyclosporin A in the Regulation of Apoptosis Current Topics in Microbiology and Immunology. ,vol. 200, pp. 95- 105 ,(1995) , 10.1007/978-3-642-79437-7_7
G C Gobé, B V Harmon, J F Kerr, N I Walker, Patterns of cell death. Experimental pathology. ,vol. 13, pp. 18- 54 ,(1988)
John T. Isaacs, Robert W. Tucker, Paula Martikainen, Natasha Kyprianou, Programmed death of nonproliferating androgen-independent prostatic cancer cells. Cancer Research. ,vol. 51, pp. 4693- 4700 ,(1991)
P. S. Mattila, K. S. Ullman, S. Fiering, E. A. Emmel, M. McCutcheon, G. R. Crabtree, L. A. Herzenberg, The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes The EMBO Journal. ,vol. 9, pp. 4425- 4433 ,(1990) , 10.1002/J.1460-2075.1990.TB07893.X
David J. McConkey, Pia Hartzell, Pierluigi Nicotera, Sten Orrenius, Calcium-activated DNA fragmentation kills immature thymocytes. The FASEB Journal. ,vol. 3, pp. 1843- 1849 ,(1989) , 10.1096/FASEBJ.3.7.2497041
K Ohno, T Nakano, Y Matsumoto, T Watari, R Goitsuka, H Nakayama, H Tsujimoto, A Hasegawa, Apoptosis induced by tumor necrosis factor in cells chronically infected with feline immunodeficiency virus Journal of Virology. ,vol. 67, pp. 2429- 2433 ,(1993) , 10.1128/JVI.67.5.2429-2433.1993
K Tokunaga, Y Nishino, H Oikawa, C Ishihara, T Mikami, K Ikuta, Altered cell tropism and cytopathicity of feline immunodeficiency viruses in two different feline CD4-positive, CD8-negative cell lines. Journal of Virology. ,vol. 66, pp. 3893- 3898 ,(1992) , 10.1128/JVI.66.6.3893-3898.1992
A Steinkasserer, R Harrison, A Billich, F Hammerschmid, G Werner, B Wolff, P Peichl, G Palfi, W Schnitzel, E Mlynar, Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication. Journal of Virology. ,vol. 69, pp. 814- 824 ,(1995) , 10.1128/JVI.69.2.814-824.1995
D Braaten, E K Franke, J Luban, Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses. Journal of Virology. ,vol. 70, pp. 4220- 4227 ,(1996) , 10.1128/JVI.70.7.4220-4227.1996
W C Brown, L Bissey, K S Logan, N C Pedersen, J H Elder, E W Collisson, Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes. Journal of Virology. ,vol. 65, pp. 3359- 3364 ,(1991) , 10.1128/JVI.65.6.3359-3364.1991