mRNA expression of chemokine receptors on peripheral blood mononuclear cells and correlation with clinical features in systemic lupus erythematosus patients.
作者： Yu-mei Li , Zhi-qiang Chen , Xu Yao , Ai-zhen Yang , An-sheng Li
DOI: 10.1016/S1001-9294(10)60042-9
关键词:
摘要: Objective To investigate the expressions of chemokine receptors and interleukin (IL) on peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients their correlations with clinical features as well SLE disease activity index (SLEDAI). Methods The mRNA (expressions IL PBMCs 93 30 healthy controls were detected by reverse transcription-polymerase chain reaction, including CCR2, CCR3, CCR4, CCR5, CCR6, CCR8, CXCR3, CXCR5, CX3CR1, XCR1, IL-4R, IL-10R. recorded. SLEDAI assayed using linear regression analysis. Results level CCR5 in (including active inactive SLE) was significantly higher than that ( P r =0.424, t =4.313, =0.518, =5.410, =0.376, =3.851, =0.457, =4.513, =0.455, =4.629, =0.445, =4.523, =0.540, =5.445, =0.313, =2.353, =0.426, =−2.155, Conclusion Increased CX3CR1 may be indicators survey for SLE.
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sci-hub.se 参考文章(25)
Robert G. Lahita, 16 – THE CLINICAL PRESENTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS Systemic Lupus Erythematosus (Fourth Edition). pp. 525- 539 ,(2011) , 10.1016/B978-0-12-374994-9.10030-0
Sabrine el-Eissawy, Jamal Al-Saleh, The role of T helper cell subsets in pathogenesis of Systemic Lupus Erythematosus and their relation to disease activity. The Egyptian journal of immunology / Egyptian Association of Immunologists. ,vol. 13, pp. 41- ,(2006)
Albert Zlotnik, Osamu Yoshie, Chemokines: A New Classification System and Their Role in Immunity Immunity. ,vol. 12, pp. 121- 127 ,(2000) , 10.1016/S1074-7613(00)80165-X
Sanjiv A. Luther, Jason G. Cyster, Chemokines as regulators of T cell differentiation Nature Immunology. ,vol. 2, pp. 102- 107 ,(2001) , 10.1038/84205
Craig Gerard, Barrett J. Rollins, Chemokines and disease Nature Immunology. ,vol. 2, pp. 108- 115 ,(2001) , 10.1038/84209
Charles R. Mackay, Chemokines: immunology's high impact factors Nature Immunology. ,vol. 2, pp. 95- 101 ,(2001) , 10.1038/84298
Jared M. Odegard, Leah D. DiPlacido, Lark Greenwald, Michael Kashgarian, Dwight H. Kono, Chen Dong, Richard A. Flavell, Joe Craft, ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus Journal of Immunology. ,vol. 182, pp. 4076- 4084 ,(2009) , 10.4049/JIMMUNOL.0800758
Paolo Fraticelli, Marina Sironi, Giancarlo Bianchi, Daniele D’Ambrosio, Cristina Albanesi, Antonella Stoppacciaro, Marcello Chieppa, Paola Allavena, Luigi Ruco, Giampiero Girolomoni, Francesco Sinigaglia, Annunciata Vecchi, Alberto Mantovani, Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses Journal of Clinical Investigation. ,vol. 107, pp. 1173- 1181 ,(2001) , 10.1172/JCI11517
P. Enghard, J. Y. Humrich, B. Rudolph, S. Rosenberger, R. Biesen, A. Kuhn, R. Manz, F. Hiepe, A. Radbruch, G.-R. Burmester, G. Riemekasten, CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients. Arthritis & Rheumatism. ,vol. 60, pp. 199- 206 ,(2009) , 10.1002/ART.24136
Hui Huang, Fang Li, Chantelle M. Cairns, John R. Gordon, Jim Xiang, Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin. Biochemical and Biophysical Research Communications. ,vol. 281, pp. 378- 382 ,(2001) , 10.1006/BBRC.2001.4363