Melanoma Stem Cells

摘要: The concept that tumor initiation and growth may be driven by a subpopulation of malignant cells, is, cancer stem cells (CSCs), has received considerable attention been validated experimentally. CSC predicts the design novel therapies ablate CSCs or target CSC-specific protumorigenic signaling pathways might result in more durable therapeutic responses patients than those achieved approaches targeted predominantly at non-CSC bulk populations. Evidence for existence generated broad range human malignancies, including melanomas as melanoma-initiating (MMICs). Several recent studies have documented specific relationship MMICs to melanoma progression resistance, recently approved therapies. Moreover, proof-of-principle potential utility targeting provided demonstrating selective killing can inhibit growth. biological mechanisms which fuel tumorigenic process started elucidated. In this chapter, we will discuss importance these translationally relevant research developments identification targets prognostic biomarkers melanoma.