The IgE-mediated release of an eosinophil leukocyte chemotactic factor from human lung.

摘要: Following antigenic challenge of human lung passively sensitized with serum from a ragweed-sensitive donor, the anaphylactic diffusate contained, in addition to histamine and slow reacting substance anaphylaxis (SRS-A), factor selectively chemotactic for eosinophils (ECF-A). ECF-A evoked migration obtained blood number donors eosinophilia. was distinguished histamine, bradykinin, serotonin, prostaglandins PGE1, PGE2 PGF2α SRS-A. The immunoglobulin mediating release IgE. Heating or absorption rabbit antibody specific IgE removed its ability sensitize mediator release, anti-IgE released normal lung. ECF-A, unique reaction, has been identified tissue.