Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
作者： Kotaro Miyake , Mitsuo Shimada , Masanori Nishioka , Koji Sugimoto , Erdenebulgan Batmunkh
DOI: 10.1007/S00280-009-0937-5
关键词:
摘要: Purpose It is well known that hypoxic milieu the primary cancer environment. Therefore, tumor hypoxia considered to be a potential therapeutic target. In present study, we investigated antitumor and antimetastatic effect of cell radiosensitizer, TX-1877 on xenograft model rectal cancer.
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