Intra-cerebrospinal fluid antibiotics to treat central nervous system infections: A review and update

摘要: Abstract Central nervous system infections can be complications of neurosurgical procedures or occur spontaneously, and occasionally lead to devastating neurological complications, increased rate mortality, lengthier stays in the hospital, subsequently increasing costs. The use intrathecal antibiotics bypass blood brain barrier provide effective concentrations central has been described as an adjunct treatment option. However, regimens utilized intrathecally have not standardized. Our review literature included all articles from MEDLINE/PubMed Ovid inception 2017 after removing duplicates checking for relevancy, final number yielded was 200. This summarizes treat CNS infections, dosages, therapeutic efficacies, highlights significant side effects. current rates mortality patients suffering is high, thus antibiotic therapy should considered a potential strategy this patient population. Multiple demonstrated safety efficacy when used intrathecally, further studies, including clinical trials, need performed elucidate their full outline proper dosing regimens.