Cyclosporine in pediatric kidney transplantation.

摘要: Before the era of cyclosporine (CsA), immunosuppression with azathioprine and steroids resulted in high rejection rates severe growth retardation pediatric renal transplant recipients. In early 1980s, CsA was introduced for children. Because differences metabolism relation weight body surface area, special dosing regimens monitoring strategies had to be developed. Use led a decreased number acute rejections and, consequently, marked increase graft survival rates. The transplanted children were significantly higher under CsA-based than classical regimens. This due need steroid co-administration. Main side effects nephrotoxicity hirsutism. introduction mircroemulsion 1990s more reliable absorption profiles lower interindividual variability area-under-the-curve concentrations thus another improvement New strategies, based on levels taken 2 hours' postdose, seem promising. transplantation, is often successfully combined an antibody-induction therapy order reduce rejections. Combination mycophenolate mofetil reduces appearance chronic rejection. Additional ToR inhibitors might enforce reduction doses therefore lead toxic effects.