Quinolizidinyl-benzimidazoles as platelet-antiaggregating agents.
作者： Iana Vazzana , Emanuela Terranova , Bruno Tasso , Michele Tonelli , Antonietta Piana
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摘要: Two series of (+/-)-2-phenyl-1-(quinolizidin-1 alpha-yl)benzimidazoles, 12A-26A, and beta-yl)benzimidazoles, 12B-26B, were prepared tested for the inhibition human platelets aggregation induced by ADP, collagen, adrenaline. All epimers A, i.e., devoid any activity against three agonists, while B, exhibited different degrees activity, though practically confined ADP-induced aggregation. The best compounds 19B, 24B, 26B, which inhibited 69-67% at 260 microM 40-29% 65 concentration ADP (2 microM)-induced observed agonist spatial structure selectivity warrant further investigations this kind benzimidazole derivatives.
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