The role of ephrins' receptors and ephrins' ligands in normal placental development and disease
作者： Nikolaos A Chatzizacharias , Constantinos T Giaginis , Emmanuel Agapitos , Stamatios E Theocharis
DOI: 10.1517/14728222.2014.864638
关键词:
摘要: Introduction: Ephrin (Eph) receptors and their membrane-anchored ligands, the ephrins, participate in a wide spectrum of pathophysiological processes, regulating cellular adhesion, migration or chemo-repulsion tissue/cell boundary formation. Recent evidence has further extended role Eph ligands as critical regulators vascular remodelling during embryogenesis. The Ephs/ephrins signalling angiogenic development murine placentas invasion maternal tissues placental vasculature humans currently attracted considerable interest. Areas covered: A literature review summarising most recent data terms normal disease, highlighting on expression status different populations vascularity. Expert opinion: Despite fact that Eph/ephrins is still unclear, some st...
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