Haemolytic activity of formyl- and acetyl-derivatives of bile acids and their gramine salts.
作者： Weronika Kozanecka-Okupnik , Beata Jasiewicz , Tomasz Pospieszny , Monika Matuszak , Lucyna Mrówczyńska
DOI: 10.1016/J.STEROIDS.2017.07.003
关键词:
摘要: Bile acids (lithocholic: LCA, deoxycholic: DCA and cholic: CA) their formyl- acetyl-derivatives can be used as starting material in chemical synthesis of compounds with different biological activity strongly depended on structures. Our previous studies showed that bile salts gramine toward human erythrocytes was significantly from the alone. Moreover, effectively modified membrane perturbing other steroids. As a continuation our work, haemolytic acetyl-substituet well studied vitro. The structures new were confirmed by spectral (NMR, FT-IR) analysis, mass spectrometry (ESI-MS) PM5 semiempirical methods. results shown acetyl-LCA higher comparison native forms at whole concentration range. At high concentration, formyl derivative CA effective LCA derivatives whereas lower its level original acid. acetyl-CA not active agents. Furthermore, decreased membrane-perturbing hydrophobic derivatives. obtained cellular system are line physicochemical calculation.
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