Mesenchymal Stem Cells During Tumor Formation and Dissemination

摘要: The tumor microenvironment (TME) is composed by malignant and non-malignant cells, all embedded in a dense extracellular matrix (ECM) rich with unstable vessels. Targeting TME components, especially those associated the vasculature such as endothelial cells (ECs) pericytes, has shown clinical benefits. identity correlation between pericytes mesenchymal stem (MSC) broadened functional roles of these adult now tightly involved cancer biology. This review summarizes this involvement, focusing on their participation in: 1) skeletal primary malignancies; 2) formation distant tumors; 3) intravasation at 4) extravasation target organ. Given tropism to sites injury inflammation, bone marrow (BM)-derived MSC (BM-MSC) follow tumor-derived signals participate tumors, repopulating perivascular habitat contributing growth. Thus, targeting tumor’s severely reduces growth, yet dissemination constitutive increases. impact pericyte-deficient coverage organ rather opposite, generating selective reduction cell invasion some organs. These seem be founded distinct molecular communication physical interactions cells.