Synthesis and structure of 1-tert-butyl-substituted 3(5)-alkylpyrazoles from 2-chlorovinyl ketones
作者： V. A. Kobelevskaya , L. I. Larina , A. V. Popov , E. V. Rudyakova , G. G. Levkovskaya
DOI: 10.1134/S1070428015020177
关键词:
摘要: Reactions of alkyl, halomethyl 2-chlorovinyl ketones with tert-butylhydrazine in the presence triethylamine afford unsymmetrical 1-(tert-butyl)-3- and -5-disubstituted pyrazoles. The reaction direction is governed by ketone ability nucleophilic substitution chlorine dehydrochlorination leading to acetylene ketones. 2-Chlorovinyl react along two routes giving mixtures -5-alkylpyrazoles. content 3-alkyl-1-(tert-butyl)pyrazole formed isomers mixture grows up 73% growing length alkyl chain 87 94% at introducing halogen atom fragment chloroenone.
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