Co-existent sickle cell disease and juvenile rheumatoid arthritis. Two cases with delayed diagnosis and severe destructive arthropathy.

摘要: We describe 2 pediatric patients with sickle cell disease (SCD) who developed seropositive juvenile rheumatoid arthritis (JRA). Both have severe joint damage, the compound effect of both processes. The bone and cartilage destruction, which poses serious therapeutic challenges, highlights difficulty making a diagnosis chronic inflammatory in setting SCD. There may be correlation between increased levels tumor necrosis factor-alpha synovial tissue joints damaged by local sickling. resultant ischemia corresponding infiltrates could turn worsen existing proliferation destruction as well trigger further