Intestinal Microvascular Patterns During Hemorrhagic Shock

摘要: While injuries due to a hypoxic state commonly appear later in both intestinal crypts and basal portion of the villi than apical portion, nonhomogeneous distribution blood flow mucosa may be supposed. The presence two different microvascular plexuses inside mucosa, corresponding cryptal plexus villous plexus, supports above hypothesis. This work studies microvasculature shocked versus normal rats. Forty-five rats were divided into four groups study histological damage bed by ink injection, fluorescent microsphere infusion, resin injection for scanning electron microscopy (SEM) vascular corrosion cast (VCC) observations. An infusion pressure 100 +/- 5 mm Hg was used control animals, while 30 adopted controls as well animals simulate physiological or shock conditions. Hemorrhagic induced removing maintaining mean arterial 45-120 mins. A close connection among patterns obtained with VCC technique can appreciated. In whole visualized, but injected at low could found, generally showing highly incomplete visualization network. significant decrease entire is present when compared unshocked controls, no difference observed. These observations suggest that perfused preferentially during hemorrhagic shock, consequence its peculiar organization. explain relative resistance crypts, villi, order sustain endocrine function regenerative capability after prolonged hypoperfusion conditions lead temporary loss barrier function.