Passive modulation of blood-group antigens.

摘要: Abstract Rh-positive erythrocytes were enriched and depleted of membrane cholesterol, the mediated change in degree exposure D antigens was determined by fluorescence-activated cell sorting, using indirect fluorescent antibody labeling. The results are compatible with a model which expression can be modulated significantly lipid microviscosity (eta). At high cholesterol-to-phospholipid ratio (C/PL) 1.55, corresponds to eta (25 degrees C) = 7.5 poise (1 0.1 Pa.sec), relative detectable number about double than that at C/PL 0.65, 4.1 poise. In analogous experiments similar fluidity changes resulted only 20% modulation A1 antigen, suggesting native state this antigen is already well exposed on erythrocyte surface. This type antigenic may also operate vivo, thus bear some fundamental implications tumor immunology autoimmune diseases.