Differential effects of a computerized cognitive stimulation program on older adults with mild cognitive impairment according to the severity of white matter hyperintensities.

摘要: Objective This study aimed to explore whether a computerized cognitive stimulation program (CCS) induced differential effects in older adults with mild impairment (MCI) according the severity of white matter hyperintensities (WMH), which are associated and increased risk progression Alzheimer's disease because damage they cause cortical subcortical networks. Patients methods Twenty-nine MCI patients no or little WMH (MCI-non-WMH) 22 moderate severe (MCI-WMH) attended 24-session CCS (two sessions per week for duration 3 months) focused on executive functions, attention, processing speed. Cognitive psychosocial assessments were performed at baseline, postintervention, months after intervention. Results Both groups improved several measures However, MCI-non-WMH group higher number than MCI-WMH group. At postintervention assessment, had more beneficial effect regard improving categorical fluency (4.6±6.8 vs 0.4±6.4; size=0.37; p=0.002). During 3-month follow-up significantly score improvements observed paired-associate learning test (6.4±3 4.7±3.5 points; size=0.43; p=0.005) as well (3.8±7.8 -0.7±6 size=0.55; p=0.0003). Conclusions These findings suggest that was related improvement by highlight importance considering interventional studies subjects MCI.