RNA polyadenylation in prokaryotes and organelles; different tails tell different tales

摘要: The addition of poly(A) tails to RNA is a phenomenon common almost all organisms examined as today. In eukaryotes, stable tail added the 3′ end most nuclear-encoded mRNAs. This process important for mRNA stability and translation initiation. addition, polyadenylation transcripts in yeast was recently reported promote degradation. prokaryotes organelles, molecules are polyadenylated part polyadenylation-dependent degradation mechanism. consists sequentially endonucleolytic cleavage, degradation-inducing poly(A)-rich sequences these cleavage products, exonucleolytic spinach chloroplasts latter two steps, degradation, performed by single phosphorolytic processive enzyme, polynucleotide phosphorylase (PNPase), while there no equivalent E. coli poly(A)-polymerase enzyme. also found be case cyanobacteria, ...