Complexation of the Non-steroidal Anti-inflammatory Drug Nabumetone with Modified and Unmodified Cyclodextrins
作者： Margarita Valero , Silvia M. B. Costa , José R. Ascenso , M. Mercedes Velázquez , Licesio J. Rodríguez
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摘要: The inclusion of the anti-inflammatory drug, Nabumetone, in α-, β- and hydroxypropyl-β-cyclodextrin (CDs) is studied using UV-VIS absorption steady-state fluorescence emission. Binding constants thermodynamic parameters complex formation are determined by spectrofluorimetry. phenomena Nabumetone with three cyclodextrins compared that well known similar drug Naproxen. In case pronounced differences observed complexation process each cyclodextrin whereas respective Naproxen complexes nearly identical. 1H-NMR experiments show can occur either through substituents -2 (butanone) or -6 (methoxy) positions naphthalene ring.
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