Genetic diversity of the cardiopulmonary canid nematode Angiostrongylus vasorum within and between rural and urban fox populations.

摘要: Abstract Angiostrongylus vasorum is an emerging parasitic cardiopulmonary nematode of dogs, foxes, and other canids. In the infection causes respiratory bleeding disorders along with clinical signs collectively known as canine angiostrongylosis, while foxes represent important wildlife reservoir. Despite spread A. across various countries in Europe Americas, little about genetic diversity populations at a local level highly endemic area. Thus, present study, we investigated 323 adult nematodes from 64 living canton Zurich, Switzerland. Among those, 279 worms isolated 20 were analyzed separately to investigate multiple within individual foxes. Part mitochondrial cytochrome c oxidase subunit I (mtCOI) gene was amplified sequenced. Overall, 16 haplotypes identified. The analysis per host revealed 12 haplotypes, up 5 different single individuals. Higher haplotype (n = 10) urban areas than rural (n = 7) observed, shared haplotypes. Comparing our data published GenBank sequences, five found be unique Zurich population. Interestingly, obtained London same dominating haplotype. Further studies are needed clarify if this has pathogenicity that may contribute its dominance. Our findings show importance reservoir for parasite recombination indicate high fox population densities small overlapping home ranges allow events lead variability vasorum.