Chemical structure determination of DNA bases modified by active metabolites of lucidin-3-O-primeveroside.

作者: Yuji Ishii , Toshiya Okamura , Tomoki Inoue , Kiyoshi Fukuhara , Takashi Umemura

DOI: 10.1021/TX900314C

关键词:

摘要: Lucidin-3-O- primeveroside (LuP) is one of the components madder root (Rubia tinctorum L.; MR) which reported to be carcinogenic in kidney and liver rats. Since metabolism LuP gener...

参考文章(20)
Jin J Wang, William D Marshall, David G Frazer, Brandon Law, Daniel M Lewis, Characterization of DNA adducts from lung tissue of asphalt fume-exposed mice by nanoflow liquid chromatography quadrupole time-of-flight mass spectrometry. Analytical Biochemistry. ,vol. 322, pp. 79- 88 ,(2003) , 10.1016/J.AB.2003.07.001
Frederick A. Beland, Mona I. Churchwell, Linda S. Von Tungeln, Shoujun Chen, Peter P. Fu, Sandra J. Culp, Bernadette Schoket, Erika Győrffy, János Minárovits, Miriam C. Poirier, Elise D. Bowman, Ainsley Weston, Daniel R. Doerge, High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts. Chemical Research in Toxicology. ,vol. 18, pp. 1306- 1315 ,(2005) , 10.1021/TX050068Y
Brunhilde Blömeke, Barbara Poginsky, Christoph Schmutte, Hildegard Marquardt, Johannes Westendorf, Formation of genotoxic metabolites from anthraquinone glycosides, present in Rubia tinctorum L. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. ,vol. 265, pp. 263- 272 ,(1992) , 10.1016/0027-5107(92)90055-7
Jeong-Yun Choi, F.Peter Guengerich, Adduct Size Limits Efficient and Error-free Bypass Across Bulky N2-Guanine DNA Lesions by Human DNA Polymerase η Journal of Molecular Biology. ,vol. 352, pp. 72- 90 ,(2005) , 10.1016/J.JMB.2005.06.079
Barbara Poginsky, Johannes Westendorf, Brunhilde Blömeke, Hans Marquardt, Alan Hewer, Philip L. Grover, David H. Phillips, EVALUATION OF DNA-BINDING ACTIVITY OF HYDROXYANTHRAQUINONES OCCURRING IN RUBIA TINCTORUM L Carcinogenesis. ,vol. 12, pp. 1265- 1271 ,(1991) , 10.1093/CARCIN/12.7.1265
Kaoru Inoue, Midori Yoshida, Miwa Takahashi, Makoto Shibutani, Hironori Takagi, Masao Hirose, Akiyoshi Nishikawa, Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study Food and Chemical Toxicology. ,vol. 47, pp. 184- 191 ,(2009) , 10.1016/J.FCT.2008.10.031
Charles N. Falany, Molecular enzymology of human liver cytosolic sulfotransferases Trends in Pharmacological Sciences. ,vol. 12, pp. 255- 259 ,(1991) , 10.1016/0165-6147(91)90566-B
Suse Broyde, Lihua Wang, Ling Zhang, Olga Rechkoblit, Nicholas E. Geacintov, Dinshaw J. Patel, DNA Adduct Structure–Function Relationships: Comparing Solution with Polymerase Structures Chemical Research in Toxicology. ,vol. 21, pp. 45- 52 ,(2008) , 10.1021/TX700193X
Andreas F. Lehner, Jamie Horn, James W. Flesher, Mass spectrometric analysis of 7-sulfoxymethyl-12-methylbenz[a]anthracene and related electrophilic polycyclic aromatic hydrocarbon metabolites. Journal of Mass Spectrometry. ,vol. 39, pp. 1366- 1378 ,(2004) , 10.1002/JMS.730