Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin.

摘要: Purpose The goal was to directly deliver curcumin, a natural polyphenolic anticancer and anti-inflammatory compound, the lung tissues with minimal systemic exposure through fabrication of proliposomes, overcoming its poor aqueous solubility oral bioavailability. Methods Nano-spray drying employed prepare proliposomes using hydroxypropyl beta-cyclodextrin as carrier. Lecithin cholesterol were used lipids, stearylamine Poloxamer 188 added positive charge inducer surfactant, respectively. Different characterization parameters evaluated like percentage yield, entrapment efficiency, drug loading, aerodynamic particle size, in vitro release besides morphological examination. Cytotoxicity studies on cell line A549 tumor cells well vivo pharmacokinetic also carried. Results optimized formulations showed superior aerosolization properties coupled their enhanced ability reach deep high % fine fraction. MTT assay demonstrated growth inhibitory effect significant reduction proinflammatory cytokines such necrosis factor-α, interleukin-6 interleukin-10 compared pure drug. tests confirmed superiority proliposomal curcumin over powder both, rate extent tissue absorption, mean residence time within tissues. Conclusion pulmonary delivery curcumin-loaded dry provides direct approach targeting while avoiding limitations route offering non-invasive alternative parenteral one.