Rare hydroperoxyl guaianolide sesquiterpenes from Pulicaria undulata
作者： Mohamed-Elamir F. Hegazy , Seikou Nakamura , Wafaa A. Tawfik , Nahla S. Abdel-Azim , Ahmed Abdel-Lateff
DOI: 10.1016/J.PHYTOL.2015.03.019
关键词:
摘要: Abstract Pulicaria species, such as undulata , are rich in sesquiterpene lactones. The methylene chloride/methanol (1:1) extract of P. resulted the isolation new sesquiterpenes ( 1 – 4 ), well previously reported metabolites 5 14 ). Structures were elucidated by spectroscopic analyses. Using a mouse peritoneal macrophage bioassay, lipopolysaccharide-induced nitric oxide inhibition was observed with eudesman-type β ,4 -dihydroxy-5 α H,7 H,8 -guaia-10(14),11(13)-dien-8 ,12-olide 11 ) at an EC 50 7.2 μM.
elsevier.com
researchgate.net 
sci-hub.se 参考文章(25)
M. Abdel-Mogib, J. Jakupovic, A.M. Dawidar, M.A. Metwally, M. Abou-Elzahab, Sesquiterpene lactones and kaurane glycosides from Francoeuria crispa. Phytochemistry. ,vol. 29, pp. 2581- 2584 ,(1990) , 10.1016/0031-9422(90)85193-J
Chutha Sae-Wong, Hisashi Matsuda, Supinya Tewtrakul, Pimpimon Tansakul, Seikou Nakamura, Yukiko Nomura, Masayuki Yoshikawa, Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells. Journal of Ethnopharmacology. ,vol. 136, pp. 488- 495 ,(2011) , 10.1016/J.JEP.2011.01.013
Mohamed-Elamir F. Hegazy, Hisashi Matsuda, Seikou Nakamura, Mikuko Yabe, Tomoko Matsumoto, Masayuki Yoshikawa, Sesquiterpenes from an Egyptian herbal medicine, Pulicaria undulate, with inhibitory effects on nitric oxide production in RAW264.7 macrophage cells. Chemical & Pharmaceutical Bulletin. ,vol. 60, pp. 363- 370 ,(2012) , 10.1248/CPB.60.363
Martin J. Hewlett, Michael J. Begley, W. Antoinette Groenewegen, Stan Heptinstall, David W. Knight, Jane May, Umit Salan, Dane Toplis, Sesquiterpene lactones from feverfew, Tanacetum parthenium: isolation, structural revision, activity against human blood platelet function and implications for migraine therapy Journal of The Chemical Society-perkin Transactions 1. pp. 1979- 1986 ,(1996) , 10.1039/P19960001979
Ferdinand Bohlmann, Pradip K. Mahanta, Jasmin Jakupovic, Ramesh C. Rastogi, Arvind A. Natu, New sesquiterpene lactones from Inula species Phytochemistry. ,vol. 17, pp. 1165- 1172 ,(1978) , 10.1016/S0031-9422(00)94308-5
Snežana Trifunović, Vlatka Vajs, Zorica Juranić, Željko Žižak, Vele Tešević, Slobodan Macura, Slobodan Milosavljević, Cytotoxic constituents of Achillea clavennae from Montenegro. Phytochemistry. ,vol. 67, pp. 887- 893 ,(2006) , 10.1016/J.PHYTOCHEM.2006.02.026
Hisashi Matsuda, Iwao Toguchida, Kiyofumi Ninomiya, Tadashi Kageura, Toshio Morikawa, Masayuki Yoshikawa, Effects of sesquiterpenes and amino acid–sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages Bioorganic & Medicinal Chemistry. ,vol. 11, pp. 709- 715 ,(2003) , 10.1016/S0968-0896(02)00471-6
Nguyen Thi Luyen, Le Hoang Tram, Tran Thi Hong Hanh, Pham Thanh Binh, Nguyen Hai Dang, Chau Van Minh, Nguyen Tien Dat, Inhibitors of α-glucosidase, α-amylase and lipase from Chrysanthemum morifolium Phytochemistry Letters. ,vol. 6, pp. 322- 325 ,(2013) , 10.1016/J.PHYTOL.2013.03.015
Mi-Ran Kim, Chang-Soo Kim, Kyung-Hwa Hwang, Il-Yeong Park, Seoung-Soo Hong, Jong-Keun Son, Dong-Cheul Moon, Isolation and structures of guaianolides from Carpesium macrocephalum. Journal of Natural Products. ,vol. 65, pp. 583- 584 ,(2002) , 10.1021/NP010388R
Abdolhossein Rustaiyan, Sussan Faramarzi, Sesquiterpene lactones from Serratula latifolia Phytochemistry. ,vol. 27, pp. 479- 481 ,(1988) , 10.1016/0031-9422(88)83124-8