Differential response of Snell's and C57 black mice to chronic inhalation of cigarette smoke. Pulmonary carcinogenesis and vascular alterations in lung and heart.

摘要: There was a marked difference in response to chronic inhalation of cigarette smoke between Snell’s and C57 Black mice. After inhaling whole or its gas vapor phase, mice disclosed higher frequency earlier occurrence lung adenocarcinomas than controls, while did not develop adenocarcinomas. On the other hand, after smoke, vascular changes heart, there no such effect Since controls developed spontaneous but alterations had cancers changes, results indicate an enhancing on existing abnormalities these two strains.