Notch Signaling May Be Involved in the Abnormal Differentiation of Epidermal Keratinocytes in Psoriasis
作者： Tami Ota , Susumu Takekoshi , Tatsuya Takagi , Kanae Kitatani , Kentaro Toriumi
DOI: 10.1267/AHC.14027
关键词:
摘要: Localization of each keratin isoform differs among epidermal layers. Proliferating basal cells synthesize 14 (K14) and suprabasal express 10 (K10) in normal skin. Notch signaling is essential for keratinocyte differentiation. Notch1 expressed all layers, Notch2 the cell layer Notch3 spinous layers epidermis. It has been poorly elucidated how localization expression levels molecules are related to molecular markers K10 K14 psoriatic skin with abnormal differentiation tissue. This study aimed investigate relationship between molecules. We investigated keratins (K14 K10) Notches (1, 2, 3 4) using immunohistochemistry (n=30) (n=10). In skin, were discretely observed layer, respectively. was pan while it co-expressed some middle cells. Notch1, 3, 4 localized mainly suprabasilar lacalized epidermal, suprabasilar, basilar Protein mRNA isoforms decreased epidermis compared These data suggest that decrements these might cause aberrant leading anomalous lesions.
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