The role of withdrawal in mesocorticolimbic drug cue reactivity in opioid use disorder.

摘要: Opioid use disorder (OUD) is characterized by heightened cognitive, physiological, and neural responses to opioid-related cues that are mediated mesocorticolimbic brain pathways. Craving withdrawal key symptoms of addiction persist during physiological abstinence. The present study evaluated the relationship between response drug in OUD baseline levels craving withdrawal. We used functional magnetic resonance imaging (fMRI) examine pictures control 29 patients. Baseline measures severity, opioid craving, were assessed prior cue exposure correlated with subsequent cues. Mediation analysis was conducted test indirect effect severity on reactivity through symptoms. found symptoms, but not positively associated nucleus accumbens, orbitofrontal cortex, amygdala. Withdrawal, accumbens' did find similar effects for stimuli unrelated drugs. Our findings emphasize central role as mediator clinical correlates sensitization They suggest OUD, signal a high vulnerability