The response regulator RssB controls stability of the sigma(S) subunit of RNA polymerase in Escherichia coli.

摘要: The rpoS-encoded sigma(S) subunit of RNA polymerase is a central regulator in regulatory network that governs the expression many stationary phase-induced and osmotically regulated genes Escherichia coli. itself induced under these conditions due to an increase rpoS transcription (only rich media) translation as well stabilization protein which growing cells subject rapid turnover. We demonstrate here response regulator, RssB, plays crucial role control cellular content. rssB null mutants exhibit nearly constitutively high levels are impaired post-transcriptional growth phase-related osmotic regulation sigma(S). Whereas translational not affected, stable mutants, indicating RssB essential for contains unique C-terminal output domain first known involved