Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6.
作者： Zeruesenay Desta , Bryan A. Ward , Nadia V. Soukhova , David A. Flockhart
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摘要: We performed comprehensive kinetic, inhibition, and correlation analyses in human liver microsomes and experiments in expressed human cytochromes P450 (P450s) to identify …
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