Inflammation and insulin resistance: New targets encourage new thinking

摘要: Galectin-3 and LTB4 are pro-inflammatory molecules recently shown to directly cause insulin resistance in mouse human cells. They highly expressed the obese state, can be targeted both genetically pharmacologically improve sensitivity vivo. This expands on previous research showing that targeting inflammatory cytokines sensitizing animal models. However, translating these potential therapies into setting remains challenging. Here we review this latest research, discuss how balancing their pleiotropic functions, action of microbiome, ability identify relevant patient populations vital considerations for successful anti-inflammatory therapy.