Metabolism of 74As-labeled trivalent and pentavalent inorganic arsenic in mice

摘要: Abstract Man is exposed to different forms of arsenic in the environment but differences metabolism and toxicity are poorly understood. The between pentavalent trivalent inorganic mice following single oral administration 74 As-labeled arsenate or arsenite (0.4 4 mg As/kg body wt) was studied. Valence state administered strictly controlled, which has not always been case previous studies. In given high dose, whole retention two three times higher after exposure As(III) compared As(V). Retention also dose dependent. Five weeks administration, dose/low ratios were 6 11 for As(V) As(III). Differences found most organs studied (blood, kidney, liver, bile, brain, skeleton, skin) obvious liver bile with concentrations 2 10 groups. Red cell/plasma 2–3 close unity It suggested that observed due degree methylation subsequent elimination primarily via kidneys.