Efficient testing strategies for evaluation of xenobiotics with neuroendocrine activity
作者： Gemma Calamandrei , Francesca Maranghi , Aldina Venerosi , Enrico Alleva , Alberto Mantovani
DOI: 10.1016/J.REPROTOX.2006.04.003
关键词:
摘要: Maturation of neuroendocrine regulations is an extremely complex process made up several stages, that can be permanently affected by any exogenous substances able to interfere with the hormonal signalling at various levels. The Endocrine Disrupting Chemicals (EDCs) are a heterogeneous group xenobiotics potential endocrine activities which have been identified as priority risk factors in toxicological research. present review aimed suggesting number and behavioural endpoints used experimental studies to: (i) characterize more thoroughly functional effects developmental exposure agents known act disruptors (ii) unmask possible interferences maturation hypothalamus-hypophysis-gonad/thyroid (HHG/Th) axis different class not considered EDCs. A combined testing strategy, considering both markers endocrine/hormonal under control laboratory rodents, may evidence even subtle perturbations homeostasis, often go undetected.
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