Role of Fibroblast Growth Factor -2 and Endothelial Cell Stimulating Angiogenic Factor (ESAF) in Capillary Growth in Skeletal Muscles Exposed to Long-Term High Activity

摘要: Angiogenesis, the development of new blood vessels, is a process controlled by many different mediators, which growth factors have been considered to be key regulators. In particular, fibroblast (FGFs) are known involved in angiogenesis pathological situations e.g. tumours (Folkman and Klagsbrun, 1987), wound healing (Broadley, Aquino, Woodward, Buckley-Sturrock, Sato, Rifkin Davidson, 1989), inflammatory conditions (D’Amore, 1992), collateral vessels ischaemic heart (Schaper, Sharma, Quinkler, Markert, Wunsch Schaper, 1990) skeletal muscle (Yang, Deschenes, Ogilvie Terjung, 1996). However, FGFs do not appear cause proliferation endothelial cells uninjured tissue it has therefore established whether they play role under normal physiological when microvascular bed undamaged. During development, may vasculogenesis (Tomanek, Haung, Suvarna, O’Brien, Ratajska Sandra, 1996), but muscle, during postnatal does seem associated with basic factor FGF-2 (Hansen-Smith, Morris Joswiak, 1992).