The chronnectome as a model for Charcot's 'dynamic lesion' in functional movement disorders.

摘要: This exploratory study set out to investigate dynamic functional connectivity (dFC) in patients with jerky and tremulous movement disorders (JT-FMD). The focus this work is on brain states, which represent distinct dFC patterns that reoccur time across subjects. Resting-state fMRI data were collected from 17 JT-FMD healthy controls (HC). Symptom severity was measured using the Clinical Global Impression-Severity scale. Depression anxiety Beck Inventory (BDI) Anxiety (BAI), respectively. Independent component analysis used extract components. After computing dFC, states determined for every subject k-means clustering. Compared HC, spent more a state characterized predominantly by increasing medial prefrontal, decreasing posterior midline over time. They also tended visit frequently. In addition, transitioned significantly often between different compared incorporated their attractor, i.e., cyclic of transitions. Altogether, first demonstrates altered network dynamics may support concepts increased self-reflective processes impaired sense agency as driving factors FMD.