microRNAs in Sporadic Alzheimer’s Disease and Related Dementias

摘要: Recent studies have demonstrated that non-coding microRNAs (miRNAs), which function at the posttranscriptional level as a rheostat of transcriptome and proteome, control variety neuronal functions well survival. Studies performed in humans support idea changes miRNA expression profiles or target sequences could significantly contribute to risk major neurodegenerative diseases such Alzheimer's disease (AD) Parkinson's (PD). MiRNAs seem participate directly regulation AD-related genes, including APP BACE1/β-secretase, are involved neurotoxic Aβ peptide production; latter accumulates brains AD patients. This observation is interesting, gene dosage effects can cause genetic AD. In this regard, research appears be particularly promising for understanding very frequent poorly understood sporadic forms probably other neurological disorders.