Cervical dilatation by Lamicel—studies on the mechanism of action

摘要: Lamicel is a synthetic hydrophilic polymer tent which produces cervical softening and dilatation when inserted into the endocervical canal. To investigate mechanism of action Lamicel, intrauterine pressure levels 6-keto-prostaglandin F1 alpha, 13-14-dihydro-15-keto-prostaglandin F2 oestradiol progesterone in plasma amniotic fluid were measured patients undergoing second trimester abortion. There was no significant change any hormones during 2-h treatment with but uterine activity increased significantly for 10 min after insertion, then settled spontaneously to below pre-treatment levels. Peripheral magnesium sulphate first abortion not raised insertion Lamicel. Light microscopic examination specimens, obtained at hysterectomy from pre-treated 24 h, revealed minimum increase vascularity, mast cell population ground substance mucopolysaccharides.