Physical activity prevented age-related decline in energy metabolism in genetically obese and diabetic rats, but not in control rats

摘要: Laboratory rats are normally confined to cages that markedly restrict their physical activity. In these rats, the resting energy expenditure accounts for 90% of total daily expenditure, while activity in humans consumes 30% expenditure. Otsuka Long Evans Tokushima Fatty (OLETF) have been developed as a model non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity, and obesity is an important factor induces this strain. We implemented running-wheel exercise regimen was equivalent normal provide light OLETF rats. The purpose study determine if improves age-related decline metabolism glucose intolerance effects were also compared control (LETO) From 12 46 weeks age, performed (3000 m/day). Energy determined at 8-week intervals. typical increase body weight significantly decreased response exercise, no significant effect observed LETO basal metabolic rate (BMR) per kilogram (not whole-body weight) increased by but not At after blood hemoglobin (Hb)A1c levels, well plasma levels insulin, triglyceride, cholesterol, leptin only cholesterol Light thus appears be beneficial preventing