Matrix-assisted laser desorption/ionization mass spectrometric quantification of the mu opioid receptor agonist DAMGO in ovine plasma.
作者： Dominic M. Desiderio , Urs Wirth , Jerry L. Lovelace , Genevieve Fridland , Edward S. Umstot
DOI: 10.1002/1096-9888(200006)35:6<725::AID-JMS1>3.0.CO;2-I
关键词:
摘要: The synthetic opioid peptide analog Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol (DAMGO), which is a mu receptor-selective agonist, was quantified in ovine plasma samples with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS), using delayed extraction and reflectron. internal standard pentadeuterated DAMGO. Timed-ion selection used to select the precursor ion. analysis of post-source decay fragments improved detection sensitivity, use precursor-product ion relationship optimized specificity. For samples, inter-assay variability this method 6.4% (n = 79) intra-assay 6.0% 10). for controls 3.4% 43). profile DAMGO amount versus time determined sheep plasma, corresponding pharmacokinetic data were calculated.
sci-hub.se 参考文章(40)
M.H. Aprison, Advances in biochemical psychopharmacology: Volume 1, edited by E. Costa and P. Greengard, Raven press (1969) Neuropharmacology. ,vol. 9, pp. 179- 180 ,(1970) , 10.1016/0028-3908(70)90062-6
P E Haroldsen, K L Clay, R C Murphy, Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. Journal of Lipid Research. ,vol. 28, pp. 42- 49 ,(1986) , 10.1016/S0022-2275(20)38726-5
Michael. Karas, Franz. Hillenkamp, Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons Analytical Chemistry. ,vol. 60, pp. 2299- 2301 ,(1988) , 10.1021/AC00171A028
P. Chaurand, F. Luetzenkirchen, B. Spengler, Peptide and protein identification by matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source decay time-of-flight mass spectrometry Journal of the American Society for Mass Spectrometry. ,vol. 10, pp. 91- 103 ,(1999) , 10.1016/S1044-0305(98)00145-7
Jozef J. Kusmierz, R. Sumrada, Dominic M. Desiderio, Fast atom bombardment mass spectrometric quantitative analysis of methionine-enkephalin in human pituitary tissues. Analytical Chemistry. ,vol. 62, pp. 2395- 2400 ,(1990) , 10.1021/AC00220A026
K. M. Foley, I. A. Kourides, C. E. Inturrisi, R. F. Kaiko, C. G. Zaroulis, J. B. Posner, R. W. Houde, C. H. Li, β-Endorphin: Analgesic and hormonal effects in humans Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 5377- 5381 ,(1979) , 10.1073/PNAS.76.10.5377
DH Chace, JC DiPerna, EW Naylor, Laboratory integration and utilization of tandem mass spectrometry in neonatal screening: a model for clinical mass spectrometry in the next millennium. Acta Paediatrica. ,vol. 88, pp. 45- 47 ,(2007) , 10.1111/J.1651-2227.1999.TB01156.X
Jozef J. Kusmierz, Chhabil Dass, James T. Robertson, Dominic M. Desiderio, Mass spectrometric measurement of β-endorphin and methionine enkephalin in human pituitaries. Tumors and post-mortem controls International Journal of Mass Spectrometry and Ion Processes. ,vol. 111, pp. 247- 262 ,(1991) , 10.1016/0168-1176(91)85058-T
Steven C. Goheen, Karen L. Wahl, James A. Campbell, Wayne P. Hess, Mass Spectrometry of Low Molecular Mass Solids by Matrix‐assisted Laser Desorption/Ionization Journal of Mass Spectrometry. ,vol. 32, pp. 820- 828 ,(1997) , 10.1002/(SICI)1096-9888(199708)32:8<820::AID-JMS538>3.0.CO;2-Q
Wolf D. Lehmann, Martin Koester, Gerhard Erben, Dietrich Keppler, Characterization and Quantification of Rat Bile Phosphatidylcholine by Electrospray–Tandem Mass Spectrometry Analytical Biochemistry. ,vol. 246, pp. 102- 110 ,(1997) , 10.1006/ABIO.1996.9941