Feline Pituitary-Dependent Hyperadrenocorticism and Insulin Resistance Due to a Plurihormonal Adenoma

摘要: A 12-year-old female spayed domestic short-haired cat presented for lethargy, poor hair coat, alopecia, difficulty walking, and mild polyuria/polydipsia. The cat's skin tore easily in the neck area during routine restraint blood draw. Physical examination, analysis, ultrasound imaging were all consistent with pituitary-dependent hyperadrenocorticism (PDH) secondary insulin-resistant diabetes mellitus, which was nonketotic. Insulin therapy, fluids, diet change initiated mellitus owner reported improvement clinical signs although glucose measurements remained elevated. Surgical repair of torn successful. Although a guarded prognosis given to because an advanced stage hyperadrenocorticism, limited treatment options currently available feline PDH, trilostane agreed on as initial therapeutic option. day be initiated, dyspnea chose euthanize. Because rarity disease cat, permission obtained by necropsy confirm suspected PDH underlying cause insulin resistance fragility syndrome.