Risk factors associated with late cytomegalovirus reactivation after allogeneic stem cell transplantation for hematological malignancies.

摘要: We analyzed the clinical factors associated with late cytomegalovirus (CMV) reactivation in a group of 269 consecutive recipients allogeneic stem cell transplant (SCT) for hematological malignancies. Eighty-four subjects (31%) experienced CMV reactivation, including 64 prior early and 20 isolated reactivation. Multivariate analyses were conducted patients to identify recurrence. Important risk included lymphoid diagnosis, occurrence graft-versus-host disease (GVHD), greater number episodes persistent day 100 lymphopenia use CMV-seronegative donor graft. combined these predictive model those at relatively low, intermediate high risk. The low-risk (15% cumulative incidence, CI) encompassed without transplanted myeloid malignancy from matched-related (MR) subsequent acute GVHD. high-risk (73% met all following criteria: (1) received an MR graft but developed GVHD, or non-MR irrespective GVHD; (2) had more than two reactivation; (3) and/or remained persistently lymphopenic after SCT. remaining incidence 32%.