Smoking habits and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort
作者： Aysel Müezzinler , Ute Mons , Aida Karina Dieffenbach , Katja Butterbach , Kai-Uwe Saum
DOI: 10.1016/J.EXGER.2015.07.002
关键词:
摘要: Abstract Background & aims Leukocyte telomere length (LTL) shortens with age and short LTL has been associated increased mortality risk for some age-related outcomes. This study to analyse the associations of smoking habits rate change per year in older adults. Methods was measured by quantitative PCR at baseline 3600 adults, who were enrolled a population-based cohort Germany. For longitudinal analyses, measurements repeated blood samples obtained 8-year follow-up from 1000 participants. Terminal Restriction Fragment analysis additionally performed sub-sample obtain absolute base pairs. Multivariate linear regression models used estimate changes over time. Results inversely (r = − 0.090, p Conclusions Our cross-sectional supports suggestions that might contribute shortening but this relationship could not be shown longitudinally. The overall rather small effect sizes observed smoking-related variables suggest reflects health hazards only very limited extent.
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