The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs

摘要: Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t 1/2 compared with other isotypes. Circumstantial evidence suggests that MHC class I-related protein, neonatal FcR (FcRn), is responsible for both in vivo functions. To understand phenotypes imposed by FcRn, we produced analyzed mice a defective FcRn gene. The results provide direct perinatal transport protection catabolism mediated latter function key homeostasis, essential generating potent response foreign Ags, basis enhanced efficacy Fc-IgG-based therapeutics. therefore promising therapeutic target enhancing protective humoral immunity, treating autoimmune disease, improving drug efficacy.