In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice.

作者: Todd S. Barry , Barton F. Haynes

DOI: 10.1007/BF00920788

关键词:

摘要: The discovery of the SCID mouse mutation has been an important advance for study human lymphopoiesis and autoimmunity. Further work in models described this review should yield new information related to transplantation hematopoietic stem cells across HLA barriers, characterization development vivo, identification pathogenic T cell clones organ-specific autoimmune diseases. If pluripotent can be defined using recipients, would pave way novel strategies bone marrow interventional immunotherapy diseases targeted at receptor (99).

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