"End-Only" Functionalized Oligo(phenylene ethynylene)s: Synthesis, Photophysical and Biocidal Activity
作者： Zhijun Zhou , Thomas S. Corbitt , Anand Parthasarathy , Yanli Tang , Linnea K. Ista
DOI: 10.1021/JZ101088K
关键词:
摘要: It is essential to develop alternative strategies treat infections, especially those infections caused by Staphylococcus aureus, which responsible for most skin infections. Among strategies, light-induced inactivation of pathogens appears be a promising candidate. We present four novel “end only” oligo(phenylene ethynylene)s (EO-OPE-1s) that have the ends functionalized with cationic groups and are powerful light-activated biocides against Escherichia coli, epidermidis, S. aureus. correlated biocidal activities singlet oxygen quantum yields Φ (1O2) EO-OPE-1s, higher correlates better activity. Coupled our previous work on interactions EO-OPE-1s dioleoyl-sn-glycero-3-phosphocholine (DOPC)/cholesterol vesicles, we believe process involves following: (1) penetrate bacterial membrane, (2) photosensitize generation and/or...
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