Truncated HSPB1 causes axonal neuropathy and impairs tolerance to unfolded protein stress
作者： Henna Tyynismaa , Emil Ylikallio , Svetlana Konovalova , Yogesh Dhungana , Taru Hilander
DOI: 10.1016/J.BBACLI.2015.03.002
关键词:
摘要: Background HSPB1 belongs to the family of small heat shock proteins (sHSP) that have importance in protection against unfolded protein stress, cancer cells for escaping drug toxicity stress and neurons suppression aggregates. sHSPs a conserved α-crystalline domain (ACD), flanked by variable N- C-termini, whose functions are not fully understood. Dominant missense variants HSPB1, locating mostly ACD, been linked inherited neuropathy.
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