Heteroaryl amide analogues as p2x7 antagonists

作者: Kevin Hodgetts , Jun Yuan , Qin Guo , David C. Ihle

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摘要: Heteroaryl amide analogues are provided, of Formula (I), wherein variables as described herein. Such compounds ligands that may be used to modulate specific receptor activity in vivo or vitro, and particularly useful the treatment conditions associated with pathological activation humans, domesticated companion animals livestock animals. Pharmaceutical compositions methods for using such treat disorders localization studies.

参考文章(38)
Barrie AstraZeneca R D Charnwood Martin, Toby AstraZeneca R D Charnwood Thompson, Nicholas AstraZeneca R D Charnwood Tomkinson, Rhonan AstraZeneca R D Charnwood Ford, Paul Astrazeneca R D Charnwood Willis, Adamantyl Derivates as P2x7 Receptor Antagonists ,(2005)
Micheal Astrazeneca R D Charnwood Stocks, Lilian Astrazeneca R D Charnwood Alcaraz, Timothy Astrazeneca R D Charnwood Johnson, N-adamantylmethyl derivates and intermediates as pharmaceutical compositions and processes for their preparation ,(2002)
Tatsuya Yoshiuchi, Shigeki Hibi, Yorihisa Hoshino, Mutsuko Ono, Motohiro Soejima, Tetsuya Hirakawa, Hisashi Shibata, Koichi Kikuchi, Yoshinori Takahashi, Kogyoku Shin, Mitsuhiro Ino, PYRAZOLO[1,5-a]PYRIDINES AND MEDICINES CONTAINING THE SAME ,(2002)
William A. Carroll, Derek W. Nelson, Michael F. Jarvis, Acylhydrazide p2x7 antagonists and uses thereof ,(2006)
Michael Milburn, Karl D. Normington, Chi B. Vu, Jean Bemis, Roger Xie, Joseph J. Nunes, Jill Milne, Fused Heterocyclic Compounds and Their Use as Sirtuin Modulators ,(2006)
Tatsuya Yoshiuchi, Shigeki Hibi, Yorihisa Hoshino, Mutsuko Ono, Yoshinori Takahashi, Motohiro Soejima, Tetsuya Hirakawa, Hisashi Shibata, Koichi Kikuchi, Kogyoku Shin, Mitsuhiro Ino, IMIDAZO[1,2-b]PYRIDAZINE COMPOUND ,(2009)
Benny C Askew, Frenel F De Morin, Andrew Hague, Ellen Laber, Aiwen Li, Gang Liu, Patricia Lopez, Rana Nomak, Vincent Santora, Christopher Tegley, Kevin Yang, None, Thiazolyl urea compounds and methods of uses ,(2003)
Richard B. Sulsky, Joseph Anthony Tino, William R. Ewing, James J. Li, Guixue Yu, Jun Li, Heterocyclic aromatic compounds useful as growth hormone secretagogues ,(2005)
Alan Stobie, Hirohide Noguchi, Geoffrey Gymer, David Fenwick, Chikara Uchida, Imidazopyridine compounds as 5-HT4 receptor modulators ,(2002)