4-Aminopyridine derivatives with antiamnesic activity
作者： A Andreani
DOI: 10.1016/S0223-5234(00)00103-3
关键词:
摘要: Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also central ring tacrine, first drug approved for AD. The synthesis and pharmacological activity three derivatives, prepared with aim improving their antiamnesic activity, here described. In two these compounds connected to 4-aminobutyric acid (GABA), whereas third it 2-indolinone, i.e., skeleton linopirdine, another Ach enhancing agent. new showed potent comparison piracetam.
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