PEtab-Interoperable specification of parameter estimation problems in systems biology.

作者: Daniel Weindl , Jan Hasenauer , Jan Hasenauer , Sven Sahle , Jens Timmer

DOI: 10.1371/JOURNAL.PCBI.1008646

关键词:

摘要: Reproducibility and reusability of the results data-based modeling studies are essential. Yet, there has been-so far-no broadly supported format for specification parameter estimation problems in systems biology. Here, we introduce PEtab, a which facilitates using Systems Biology Markup Language (SBML) models set tab-separated value files describing observation model experimental data as well parameters to be estimated. We already implemented PEtab support into eight well-established simulation toolboxes with hundreds users total. provide Python library validation modification problem currently 20 example based on recent studies.

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