Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials

摘要: Background Trials have examined on the benefits of vitamin D supplementation in pregnant women. Objective This review aimed to evaluate whether oral supplements, when given women with gestational diabetes mellitus (GDM), would improve maternal and neonatal outcomes, compared no treatment or placebo. Method We performed a systematic following Cochrane methodology, randomized trials were included where GDM received versus placebo/no calcium treatment. Primary outcomes preeclampsia, preterm birth, cesarean delivery, hypertension, adverse events related supplementation. The search strategies applied databases: MEDLINE, Embase, LILACS, CENTRAL. Similar at least two plotted using Review Manager 5.3 software. quality evidence was generated according Grading Recommendations Assessment, Development, Evaluation (GRADE). Results total 1224 references identified, eleven potentially eligible, six this (totaling 456 women). meta-analysis frequency deliveries did not show significant differences between groups, none evaluated remaining primary outcomes. For secondary our results suggest that may reduce newborn complications such as hyperbilirubinemia, polyhydramnios (RR: 0.40, 95% CI: 0.23 0.68; RR: 0.17, 0.03 0.89; respectively), need for infant hospitalization 0.13; 0.02 0.98; 0.69). However, low very quality. Conclusion find moderate high indicating supplementation, placebo, improves glucose metabolism,