Integrating Prevention and Screening for Lung Cancer into Clinical Practice

摘要: Lung cancer is the leading cause of mortality worldwide. When diagnosed at an early stage, lung 5-year survival 60–70 %, but when clinically, most cancers are advanced and overall 16 %. Exposure to tobacco smoke dominant risk factor, other environment host factors also important. prevention detection through screening have potential reduce morbidity mortality. Risk prediction models can be helpful in defining target populations for both screening. Prevention currently based on avoidance use exposure. There no established chemoprevention agents cancer, this remains area active investigation. The National Screening Trial (NLST) demonstrated first time that with low-dose computed tomography (LDCT) reduces among a high-risk population. Efforts better define optimal approach development guidelines now underway. Discovery biomarkers capable detecting stage another great promise. combination LDCT future should help improve accuracy clinical utility programs. All programs incorporate access cessation resources.